Understanding how Acinetobacter baumannii resists antibiotics and causes disease
Global Circuitry that Controls Acinetobacter Resistance and Virulence
This study is looking at how a tough germ called Acinetobacter baumannii avoids being killed by antibiotics and causes serious infections, focusing on a special system that helps it stay protected, with the hope of finding new ways to treat infections for people affected by this bacteria.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northeastern University NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10877925 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which Acinetobacter baumannii, a highly antibiotic-resistant bacterium, evades treatment and causes severe infections. The focus is on a unique regulatory system called BfmRS, which controls the bacterium's protective cell envelope and its ability to resist antibiotics and evade the immune system. By studying this system, researchers aim to uncover how it contributes to the pathogen's virulence and resistance, potentially leading to new therapeutic strategies. The research involves laboratory experiments to analyze the genetic and biochemical pathways involved in this process.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients suffering from infections caused by Acinetobacter baumannii, particularly those with antibiotic-resistant strains.
Not a fit: Patients with infections caused by other types of bacteria that do not involve Acinetobacter baumannii may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new treatments that effectively combat infections caused by antibiotic-resistant Acinetobacter baumannii.
How similar studies have performed: Previous research has shown success in targeting bacterial regulatory systems to combat antibiotic resistance, suggesting that this approach may yield promising results.
Where this research is happening
Boston, United States
- Northeastern University — Boston, United States (Active)
Researchers
- Principal investigator: Geisinger, Edward — Northeastern University
- Study coordinator: Geisinger, Edward
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.