Understanding how acidosis affects lung injury in pneumonia patients
Official title: Acidosis in pulmonary endothelial injury and repair
Funded at University of South Alabama · NIH-11010777 · Data updated 2026-11-12
This study is looking at how a condition called acidosis affects pneumonia and the tiny blood vessels in the lungs, with the hope of finding better ways to diagnose and treat patients who are seriously ill with pneumonia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Alabama NIH-funded |
| Lab location | 1 site (Mobile, United States) |
| Project start | February 1, 2022 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $385,000 |
| NIH project number | 5R01HL160988-04 |
| Project ID | NIH-11010777 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are critically ill patients diagnosed with pneumonia who are experiencing acidosis.
✕Less likely to help
Patients with pneumonia who do not exhibit acidosis or those with other unrelated respiratory conditions may not benefit from this research.
What this research studies
This research investigates the impact of acidosis on pneumonia, particularly how it affects the pulmonary microvascular endothelial cells (PMVECs) that line the lungs. The study aims to uncover the mechanisms by which acidosis contributes to lung injury and the role of specific proteins in this process. By using genetic techniques and functional assays, researchers will explore how infections, particularly from Pseudomonas aeruginosa, lead to the production of harmful amyloid proteins that disrupt lung function. The ultimate goal is to establish a foundation for developing better diagnostic and therapeutic strategies for critically ill pneumonia patients.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for pneumonia patients suffering from acidosis, potentially reducing mortality rates.
How similar studies have gone: While the specific approach of this research is novel, previous studies have shown that understanding the mechanisms of acidosis in lung injury can lead to significant advancements in treatment.
Where this research is happening
-
University of South Alabama
Mobile, United States Active
Researchers
- Principal investigator: Lee, Ji Young — University of South Alabama
- Study coordinator: Lee, Ji Young
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.