Understanding how acidity affects inflammation in the gut
Control of Inflammatory Acidity in Mucosal Inflammation
This study is looking at how acidity in the gut can make inflammation worse and affect gut health, with the hope of finding new ways to help people with inflammatory bowel diseases feel better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Eastern Colorado Health Care System NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10948096 on NIH RePORTER |
What this research studies
This research investigates the role of acidity in mucosal inflammation within the gastrointestinal tract. It focuses on how the accumulation of certain immune cells, known as neutrophils, can lead to an acidic environment that may worsen inflammation and affect gut barrier function. By analyzing gene expression and metabolic changes in intestinal cells exposed to low pH, the study aims to uncover mechanisms that could help in managing inflammatory bowel diseases. Patients may benefit from insights that could lead to new treatments targeting inflammation and acidity in the gut.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from inflammatory bowel diseases or related gastrointestinal conditions.
Not a fit: Patients with non-inflammatory gastrointestinal issues or those without any gastrointestinal symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing inflammatory bowel diseases and improving gut health.
How similar studies have performed: Previous research has shown that targeting inflammatory processes in the gut can lead to significant improvements in patient outcomes, suggesting this approach may also be promising.
Where this research is happening
Aurora, UNITED STATES
- VA Eastern Colorado Health Care System — Aurora, United States (Active)
Researchers
- Principal investigator: Cartwright, Ian Michael — VA Eastern Colorado Health Care System
- Study coordinator: Cartwright, Ian Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.