Understanding how acid reflux may lead to esophageal cancer
Regulation of the JAK/STAT Signaling and Esophageal Tumorigenesis in Conditions of Esophageal Reflux Injury
['FUNDING_P01'] · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · NIH-10866611
This study is looking at how chronic heartburn (GERD) might lead to a specific type of esophagus cancer, and it's especially important for people with Barrett's esophagus or GERD because it could help find new ways to prevent or treat this cancer.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MIAMI SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (CORAL GABLES, UNITED STATES) |
| Trial ID | NIH-10866611 on ClinicalTrials.gov |
What this research studies
This research investigates the link between chronic gastroesophageal reflux disease (GERD) and the development of esophageal adenocarcinoma (EAC), a rapidly increasing cancer in the U.S. The team aims to uncover the mechanisms by which reflux causes cellular changes in the esophagus, particularly focusing on the JAK/STAT signaling pathway and protein modifications. By utilizing both animal models and human tissue samples, the research seeks to identify new preventive and treatment strategies for EAC. Patients with Barrett's esophagus or GERD may find this research particularly relevant as it could lead to better understanding and management of their conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with chronic gastroesophageal reflux disease (GERD) or Barrett's esophagus.
Not a fit: Patients without a history of GERD or Barrett's esophagus are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new preventive measures and treatments for esophageal adenocarcinoma, improving outcomes for patients at risk.
How similar studies have performed: Previous research has shown promising results in understanding the mechanisms of esophageal cancer related to reflux, but this specific approach is innovative and aims to fill existing knowledge gaps.
Where this research is happening
CORAL GABLES, UNITED STATES
- UNIVERSITY OF MIAMI SCHOOL OF MEDICINE — CORAL GABLES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZAIKA, ALEXANDER I. — UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
- Study coordinator: ZAIKA, ALEXANDER I.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancerous