Understanding how Achilles tendon injuries affect cell behavior and treatment options
Official title: Research Project 2
Funded at University of Pennsylvania · NIH-11015881 · Data updated 2026-11-12
This study is looking at how the structure of DNA in tendon cells changes when someone has Achilles tendinopathy, which could help us find better ways to treat tendon injuries and improve healing for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | February 1, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $415,597 |
| NIH project number | 5P50AR080581-03 |
| Project ID | NIH-11015881 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from Achilles tendinopathy or related tendon injuries.
✕Less likely to help
Patients with tendon injuries unrelated to the Achilles tendon may not receive benefits from this research.
What this research studies
This research investigates the changes in the 3D structure of the genome in tendon cells affected by Achilles tendinopathy, a common and costly condition. It aims to explore how these changes impact the cells' behavior and their response to various treatments, including epigenetic therapies. By examining the chemo-physical environment and the genetic factors involved, the research seeks to develop improved strategies for treating tendon injuries. Patients may benefit from new therapeutic approaches that enhance tendon repair and recovery.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for Achilles tendon injuries, improving recovery outcomes for patients.
How similar studies have gone: Other research has shown promise in using epigenetic therapies for various conditions, suggesting potential success for similar approaches in treating tendon injuries.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Heo, Su Chin — University of Pennsylvania
- Study coordinator: Heo, Su Chin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.