Understanding how acetylcholine works in the brain's striatum
Dissecting Mechanisms of Striatal Acetylcholine Transmission in the Vertebrate Brain
['FUNDING_FELLOWSHIP'] · HARVARD MEDICAL SCHOOL · NIH-10889218
This study is looking at how a brain chemical called acetylcholine works in an important area of the brain that helps with motivation and learning, and it hopes to find new ways to improve treatments for people with neurological conditions.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | HARVARD MEDICAL SCHOOL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10889218 on ClinicalTrials.gov |
What this research studies
This research investigates the role of acetylcholine in the striatum, a key area of the brain involved in controlling behaviors like motivation and learning. It aims to uncover the mechanisms of acetylcholine transmission and its interaction with dopamine, which is crucial for various neurological functions. By examining how acetylcholine is released and how it affects nearby receptors, the research seeks to clarify the signaling processes that govern brain activity. Patients may benefit from insights gained about these mechanisms, which could lead to improved treatments for neurological conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions affecting the striatum or those experiencing cognitive and behavioral issues related to acetylcholine and dopamine signaling.
Not a fit: Patients with conditions unrelated to cholinergic or dopaminergic signaling may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of brain signaling, potentially leading to better therapies for neurological disorders.
How similar studies have performed: Other research has shown promising results in understanding neuromodulator signaling, but the specific mechanisms of acetylcholine in the striatum remain largely untested.
Where this research is happening
BOSTON, UNITED STATES
- HARVARD MEDICAL SCHOOL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BEESON, KATHLEEN ALLISON — HARVARD MEDICAL SCHOOL
- Study coordinator: BEESON, KATHLEEN ALLISON
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.