Understanding how acetylcholine affects brain signaling and behavior
Spatial, temporal, and context-dependent features of GPCR-mediated protein kinase A activity
['FUNDING_R01'] · WASHINGTON UNIVERSITY · NIH-10874583
This study is looking at how a brain chemical called acetylcholine affects another important protein that helps with learning and memory, and it's for anyone interested in understanding how our brains work and how these processes might influence our behavior.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-10874583 on ClinicalTrials.gov |
What this research studies
This research investigates how acetylcholine, a key neurotransmitter, influences protein kinase A (PKA) activity in the brain, particularly in the hippocampus. By examining the spatial and temporal dynamics of this signaling, the study aims to uncover how these processes affect synaptic plasticity and behavior. Researchers will use advanced techniques, including acute brain slices and head-fixed mice, to explore the specific cellular compartments involved and how the timing and context of acetylcholine signaling impact brain function. This could lead to a better understanding of how neuromodulators like acetylcholine regulate complex brain processes.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with conditions affecting brain function or cognition, such as neurodegenerative diseases.
Not a fit: Patients with conditions unrelated to neuromodulation or those who do not have cognitive or behavioral symptoms may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of brain signaling mechanisms, potentially leading to new treatments for neurological disorders.
How similar studies have performed: While the specific approach of this research may be novel, previous studies have shown success in understanding neuromodulator signaling and its implications for brain function.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHEN, YAO — WASHINGTON UNIVERSITY
- Study coordinator: CHEN, YAO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.