Understanding how acetylation affects protein stability in cells
Editing Acetylation and Protein Homeostasis
['FUNDING_OTHER'] · UNIVERSITY OF PENNSYLVANIA · NIH-11092864
This study is looking at how a process called acetylation affects the balance of proteins in our cells, which is important for keeping them healthy, and it aims to find new ways to adjust this process to help treat certain conditions.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11092864 on ClinicalTrials.gov |
What this research studies
This research investigates the role of acetylation in regulating protein homeostasis, which is essential for maintaining healthy cells. The team will explore how proteins are tagged for degradation by the ubiquitin proteasome system and how acetylation modifies this process. By using advanced techniques like proteomics and RNA sequencing, they aim to identify proteins whose stability is influenced by acetylation. Additionally, they will develop new methods to manipulate protein acetylation as a potential therapeutic strategy.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions linked to protein homeostasis disruptions, such as certain cancers or neurodegenerative diseases.
Not a fit: Patients with conditions unrelated to protein regulation or those who do not have acetylation-related disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases related to protein mismanagement, such as cancer and neurodegenerative disorders.
How similar studies have performed: Previous research has shown promising results in understanding protein regulation through similar biochemical approaches, indicating potential for success in this area.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BURSLEM, GEORGE — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: BURSLEM, GEORGE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.