Understanding how acetylation affects heart energy function as we age
Investigating the novel role of acetylation in cardiac mitochondrial bioenergetics and function in the aging heart
['FUNDING_OTHER'] · WEST VIRGINIA UNIVERSITY · NIH-10683270
This study is looking at how a process called acetylation affects the energy-making parts of heart cells as we age, which could help us understand and improve heart health in older adults.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WEST VIRGINIA UNIVERSITY (nih funded) |
| Locations | 1 site (MORGANTOWN, UNITED STATES) |
| Trial ID | NIH-10683270 on ClinicalTrials.gov |
What this research studies
This research investigates the role of acetylation in the function of mitochondria in the aging heart. It focuses on how specific enzymes, Hydroxyacyl-CoA Dehydrogenase and Long Chain Acyl-CoA Dehydrogenase, are regulated by acetylation and how this regulation impacts energy production in heart cells. By studying these mechanisms, the research aims to uncover why mitochondrial function declines with age, which could lead to better understanding and treatment of age-related heart diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing heart-related issues or those at risk for age-related heart diseases.
Not a fit: Patients with acute heart conditions unrelated to aging or mitochondrial dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving heart function in older adults.
How similar studies have performed: Previous research has shown promising results in understanding mitochondrial function and acetylation, suggesting that this approach could yield valuable insights.
Where this research is happening
MORGANTOWN, UNITED STATES
- WEST VIRGINIA UNIVERSITY — MORGANTOWN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: THAPA, DHARENDRA — WEST VIRGINIA UNIVERSITY
- Study coordinator: THAPA, DHARENDRA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Disease