Understanding how acetylation affects heart cell regeneration
Official title: Acetylation Regulates YAP Subcellular Localization and Cardiac Regeneration
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11042358 · Data updated 2026-11-12
This study is looking at how a protein called YAP helps heart cells heal after an injury, like a heart attack, and aims to find new ways to encourage these cells to grow and repair themselves better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | January 1, 2025 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $361,083 |
| NIH project number | 1R01HL172839-01A1 |
| Project ID | NIH-11042358 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults suffering from ischemic heart diseases, particularly those who have experienced heart attacks or heart failure.
✕Less likely to help
Patients with non-ischemic heart conditions or those who are not adults may not benefit from this research.
What this research studies
This research investigates the role of acetylation in the localization of a protein called YAP, which is crucial for the regeneration of heart muscle cells after injury. By exploring how YAP moves in and out of the cell nucleus in response to various signals, the study aims to identify new therapeutic strategies to promote the natural division of heart cells, known as cardiomyocytes. The researchers will use animal models to understand the mechanisms behind YAP's function and how it can be manipulated to enhance heart repair following conditions like heart attacks.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart regeneration and recovery for patients with heart diseases.
How similar studies have gone: Previous studies have shown promising results in heart regeneration by targeting the Hippo pathway, indicating that this approach has potential based on earlier successes.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Liu, Shijie — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Liu, Shijie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.