Understanding how acetyl-CoA is regulated in cells
Official title: Imaging Spatiotemporal Regulation of Acetyl-CoA
Funded at University of California Los Angeles · NIH-10687647 · Data updated 2026-11-12
This study is looking at how a key substance called acetyl-CoA behaves in our cells, using special imaging techniques to see it in action, which can help us understand how it affects our metabolism and overall cell health based on what nutrients are available.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $1,354,522 |
| NIH project number | 1DP2GM154012-01 |
| Project ID | NIH-10687647 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with metabolic disorders or conditions that affect cellular metabolism.
✕Less likely to help
Patients with stable metabolic conditions that do not involve alterations in acetyl-CoA metabolism may not benefit from this research.
What this research studies
This research investigates the regulation of acetyl-CoA, a crucial metabolite involved in various biochemical reactions, within cells. By using advanced live cell imaging techniques and genetically encoded fluorescent biosensors, the study aims to visualize the dynamics of acetyl-CoA in real-time at the single-cell level. This approach allows researchers to explore how acetyl-CoA is compartmentalized and regulated based on nutrient availability and cellular signaling, providing insights into its role in metabolism and cellular function.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of metabolic processes and potentially inform new treatments for metabolic disorders.
How similar studies have gone: While the use of biosensors for studying metabolism is relatively novel, similar approaches have shown success in investigating other cellular processes, indicating potential for impactful findings.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Schmitt, Danielle Lynanne — University of California Los Angeles
- Study coordinator: Schmitt, Danielle Lynanne
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.