Understanding how abnormal protein signaling affects Alzheimer's disease
Official title: Aberrant Protein Kinase C Signaling in Alzheimer's Disease
Funded at University of California, San Diego · NIH-10901015 · Data updated 2026-11-12
This study is looking into how a certain protein signaling process might affect the brain in people with Alzheimer's disease, and it's hoping to find new ways to help improve treatment for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | September 15, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $908,983 |
| NIH project number | 1R56AG082903-01 |
| Project ID | NIH-10901015 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk due to genetic factors.
✕Less likely to help
Patients with early-stage cognitive impairment not related to Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates the role of abnormal protein kinase C (PKC) signaling in the development and progression of Alzheimer's disease. By examining the molecular and cellular mechanisms involved, the team aims to uncover how these signaling pathways contribute to neuronal death and cognitive decline. The study utilizes advanced techniques, including whole genome sequencing and mouse models, to explore the impact of specific genetic variants on brain function and disease pathology. Patients may benefit from insights that could lead to new therapeutic strategies targeting PKC signaling.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or prevent the progression of Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in understanding the role of protein signaling in Alzheimer's, suggesting potential for breakthroughs in treatment.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Newton, Alexandra C. — University of California, San Diego
- Study coordinator: Newton, Alexandra C.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.