Understanding how abnormal cyclin D1 gene expression affects blood cancer
Official title: Elucidating the mechanism and consequences of aberrant cyclin D1 gene expression
Funded at Butler University · NIH-10890721 · Data updated 2026-11-12
This study is looking into how a gene called cyclin D1 behaves in patients with Mantle Cell Lymphoma, a type of aggressive blood cancer, to help uncover why it acts abnormally and how that might lead to faster cancer growth, with the hope of finding new treatment options for those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Butler University NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | August 1, 2020 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $278,722 |
| NIH project number | 5R01GM135361-05 |
| Project ID | NIH-10890721 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Mantle Cell Lymphoma or other B-cell malignancies exhibiting cyclin D1 abnormalities.
✕Less likely to help
Patients with non-B-cell malignancies or those without cyclin D1 expression issues may not benefit from this research.
What this research studies
This research investigates the abnormal expression of the cyclin D1 gene in B-cell malignancies, particularly Mantle Cell Lymphoma (MCL), which is known for its aggressive nature. The study aims to uncover the molecular mechanisms that lead to the aberrant expression of cyclin D1 and its role in promoting cancer cell proliferation and genetic instability. By analyzing the pre-mRNA processing and identifying fusion genes resulting from chromosomal translocations, the research seeks to provide insights into the underlying causes of this blood cancer. Patients may benefit from a better understanding of their condition and potential new therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients with aggressive B-cell malignancies.
How similar studies have gone: Previous research has shown promising results in understanding gene expression in blood cancers, making this approach both relevant and potentially impactful.
Where this research is happening
-
Butler University
Indianapolis, United States Active
Researchers
- Principal investigator: Masamha, Chioniso Patience — Butler University
- Study coordinator: Masamha, Chioniso Patience
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.