Understanding how abnormal brain cells contribute to epilepsy after brain injuries
Molecular control of aberrant adult-born granule cells in epilepsy
This study is looking at how the brain heals after serious injuries, like a traumatic brain injury or seizures, and how new brain cells that form during recovery can sometimes act strangely and lead to epilepsy, with the goal of finding ways to prevent this from happening.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas San Antonio NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-10877035 on NIH RePORTER |
What this research studies
This research investigates the changes in brain cell development that occur after severe brain injuries, such as traumatic brain injury or status epilepticus, which may lead to epilepsy. The team will explore how new neurons, formed during this recovery period, can become abnormal and contribute to seizure activity. By studying the genes and signaling pathways involved in this process, the researchers aim to uncover the mechanisms that promote these aberrant cells and their impact on brain circuitry. This work could provide insights into potential therapeutic targets for preventing epilepsy in affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 21 and older who have experienced traumatic brain injuries or status epilepticus.
Not a fit: Patients with epilepsy not related to brain injuries or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent the development of epilepsy in patients who have suffered severe brain injuries.
How similar studies have performed: Previous research has shown that understanding the role of neurogenesis in epilepsy can lead to significant advancements in treatment, indicating that this approach has potential for success.
Where this research is happening
San Antonio, United States
- University of Texas San Antonio — San Antonio, United States (Active)
Researchers
- Principal investigator: Hsieh, Jenny — University of Texas San Antonio
- Study coordinator: Hsieh, Jenny
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.