Understanding how ABIN1 dysfunction affects kidney disease in lupus patients
ABIN1 dysfunction in Lupus Nephritis
['FUNDING_R01'] · UNIVERSITY OF LOUISVILLE · NIH-10873348
This study is looking at how a protein called ABIN1 affects kidney problems in people with lupus, especially focusing on African American patients, to understand why some people have worse symptoms than others, and it may involve some genetic testing and kidney health check-ups for participants.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF LOUISVILLE (nih funded) |
| Locations | 1 site (LOUISVILLE, UNITED STATES) |
| Trial ID | NIH-10873348 on ClinicalTrials.gov |
What this research studies
This research investigates the role of ABIN1, a protein that regulates immune responses, in lupus nephritis, a serious kidney complication of systemic lupus erythematosus, particularly in African American patients. The study aims to uncover the molecular mechanisms by which genetic variations in the TNIP1 gene, which affect ABIN1 function, contribute to the severity and progression of lupus nephritis. By analyzing immune cell types and their responses, the research seeks to clarify how these genetic factors lead to racial disparities in disease outcomes. Patients may be involved in genetic testing and monitoring of their kidney health as part of this research.
Who could benefit from this research
Good fit: Ideal candidates for this research are African American individuals diagnosed with systemic lupus erythematosus and experiencing lupus nephritis.
Not a fit: Patients who do not have systemic lupus erythematosus or lupus nephritis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and targeted treatments for lupus nephritis, particularly for African American patients who are disproportionately affected.
How similar studies have performed: Previous research has shown associations between genetic factors and lupus nephritis, indicating that this approach has potential for success in understanding the disease.
Where this research is happening
LOUISVILLE, UNITED STATES
- UNIVERSITY OF LOUISVILLE — LOUISVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: POWELL, DAVID W. — UNIVERSITY OF LOUISVILLE
- Study coordinator: POWELL, DAVID W.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.