Understanding how ABI3 gene affects Alzheimer's disease
The role of ABI3 in Alzheimers disease
This study is looking at how a gene called ABI3 affects the way certain brain cells work in Alzheimer's disease, using mice and human cells to see if changing this gene can help us understand the disease better and find new ways to treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-11089597 on NIH RePORTER |
What this research studies
This research investigates the role of the ABI3 gene in the development of Alzheimer's disease, particularly focusing on its impact on microglial function. Researchers will use mouse models and human microglial cells to explore how the deletion of ABI3 influences Alzheimer's pathology. By employing advanced techniques like transcriptomic and proteomic analyses, they aim to identify key regulators involved in the disease process. The study also examines a rare variant of the ABI3 gene to understand its effects on Alzheimer's disease progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for late-onset Alzheimer's disease, particularly those with a family history or genetic predisposition.
Not a fit: Patients with early-onset Alzheimer's disease or those without any genetic risk factors for Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and potential therapeutic targets for Alzheimer's disease.
How similar studies have performed: Other research has shown promising results in understanding genetic factors in Alzheimer's disease, making this approach both relevant and potentially impactful.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Kim, Jungsu — Indiana University Indianapolis
- Study coordinator: Kim, Jungsu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.