Understanding how a virus spreads through saliva
Unmasking the roles of viral glycoproteins in oral transmission of KSHV
This study is looking at how a virus called KSHV spreads through the mouth, especially in kids and people with weakened immune systems, to help find ways to prevent infections and possibly create a vaccine.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project ID | NIH-10977417 on NIH RePORTER |
What this research studies
This research investigates how the Kaposi sarcoma-associated herpesvirus (KSHV) is transmitted orally, particularly in children and immunocompromised individuals. By using a non-human primate model, the study aims to identify the specific viral glycoproteins necessary for the virus to enter the body through the oral cavity. The researchers will explore the mechanisms of transmission and the potential for developing a vaccine to prevent KSHV infections. This work is crucial for understanding the virus's spread and its implications for public health, especially in regions with high incidence rates.
Who could benefit from this research
Good fit: Ideal candidates for this research are children and individuals with compromised immune systems who are at risk for KSHV infections.
Not a fit: Patients who are not at risk for KSHV infections or those who are already infected may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of a vaccine that prevents KSHV infections, potentially reducing the incidence of related cancers like Kaposi sarcoma.
How similar studies have performed: While there has been significant research on KSHV, this specific approach using a non-human primate model to study oral transmission is relatively novel.
Where this research is happening
Duarte, United States
- Beckman Research Institute/city of Hope — Duarte, United States (Active)
Researchers
- Principal investigator: Ogembo, Javier Gordon — Beckman Research Institute/city of Hope
- Study coordinator: Ogembo, Javier Gordon
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.