Understanding how a virus spreads through saliva
Unmasking the roles of viral glycoproteins in oral transmission of KSHV
This study is looking at how the Kaposi sarcoma virus spreads through the mouth, especially focusing on certain proteins that help the virus infect people, and it aims to find ways to prevent this, which could be especially helpful for children and others at risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project ID | NIH-10914167 on NIH RePORTER |
What this research studies
This research investigates how the Kaposi sarcoma-associated herpesvirus (KSHV) is transmitted orally, particularly focusing on the viral glycoproteins that facilitate this process. By using a non-human primate model, the study aims to identify the specific glycoproteins necessary for the virus to infect through the oral cavity. This approach will help clarify the mechanisms of transmission and could lead to the development of a vaccine. The research is particularly relevant for understanding KSHV infections in vulnerable populations, including children.
Who could benefit from this research
Good fit: Ideal candidates for this research are children and individuals at risk of KSHV infection, especially those living in regions with high incidence rates.
Not a fit: Patients who are not at risk for KSHV infection or those who are already infected may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of an effective vaccine to prevent KSHV infections, particularly in high-risk populations.
How similar studies have performed: Previous research has shown success in understanding viral transmission mechanisms in other contexts, but this specific approach using a non-human primate model for KSHV is relatively novel.
Where this research is happening
Duarte, United States
- Beckman Research Institute/city of Hope — Duarte, United States (Active)
Researchers
- Principal investigator: Ogembo, Javier Gordon — Beckman Research Institute/city of Hope
- Study coordinator: Ogembo, Javier Gordon
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.