Understanding how a virus protein affects the immune response in different strains of influenza.
Official title: Mechanistic bases of strain-specific virus-host interactions
Funded at Texas A&m Agrilife Research · NIH-11017744 · Data updated 2026-11-12
This study is looking at how a protein from the flu virus helps it dodge our immune system, which could lead to better treatments for people fighting the flu.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m Agrilife Research NIH-funded |
| Lab location | 1 site (College Station, UNITED STATES) |
| Project start | February 1, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $329,108 |
| NIH project number | 5R35GM152007-02 |
| Project ID | NIH-11017744 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are at risk of influenza A infections, particularly those with weakened immune systems or underlying health conditions.
✕Less likely to help
Patients who are not affected by influenza A or who have already been vaccinated against it may not benefit from this research.
What this research studies
This research investigates the mechanisms by which a specific protein from the influenza A virus, known as NS1, disrupts the body's antiviral responses. By examining how NS1 interacts with host proteins and evolves over time, the study aims to uncover the molecular details of how different strains of the virus evade the immune system. The research will involve detailed biophysical analyses and structural studies to understand these interactions at a molecular level. This knowledge could lead to the development of more effective antiviral therapies.
Why it matters
Potential benefit: If successful, this research could lead to improved antiviral treatments for influenza A, potentially reducing the severity and spread of the virus.
How similar studies have gone: Previous research has shown success in understanding viral mechanisms of immune evasion, making this approach promising for further advancements.
Where this research is happening
-
Texas A&m Agrilife Research
College Station, United States Active
Researchers
- Principal investigator: Cho, Jae Hyun — Texas A&m Agrilife Research
- Study coordinator: Cho, Jae Hyun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.