Understanding how a virus protein affects gene regulation
Official title: Determining the impact of respiratory syncytial virus M2-1 protein on post-transcriptional regulation of cellular and viral mRNAs
Funded at Boston University Medical Campus · NIH-10906739 · Data updated 2026-11-12
This study is looking at a specific protein from the respiratory syncytial virus (RSV) to understand how it helps the virus grow and spread, which could lead to new ways to treat RSV infections.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 14, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $206,250 |
| NIH project number | 5R21AI174597-02 |
| Project ID | NIH-10906739 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children and young individuals under 21 years old who are at risk of RSV infection.
✕Less likely to help
Patients who are not affected by RSV or who are outside the age range of 0-21 years may not benefit from this research.
What this research studies
This research investigates the role of the M2-1 protein from the respiratory syncytial virus (RSV) in regulating the expression of viral and cellular mRNAs. By examining how this protein interacts with newly synthesized mRNAs and translation factors, the study aims to uncover mechanisms that could lead to new antiviral strategies. The research employs advanced microscopy techniques to visualize the interactions within cells, providing insights into the virus's replication process. Ultimately, this work seeks to enhance our understanding of RSV pathogenesis and inform the development of effective treatments.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antiviral therapies for RSV, potentially reducing the burden of respiratory diseases in vulnerable populations.
How similar studies have gone: Previous research has shown promise in understanding viral mechanisms similar to those being investigated in this study, indicating a potential for success.
Where this research is happening
-
Boston University Medical Campus
Boston, United States Active
Researchers
- Principal investigator: Fearns, Rachel — Boston University Medical Campus
- Study coordinator: Fearns, Rachel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.