Understanding how a virus manipulates the immune system during chronic infection.
Gammaherpesvirus protein kinase: a master manipulator of the host during chronic infection.
['FUNDING_R01'] · MEDICAL COLLEGE OF WISCONSIN · NIH-11120865
This study is looking at how a common virus that many adults have can affect the immune system and lead to certain types of blood cancers, with the hope of finding new ways to treat or prevent these conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MEDICAL COLLEGE OF WISCONSIN (nih funded) |
| Locations | 1 site (MILWAUKEE, UNITED STATES) |
| Trial ID | NIH-11120865 on ClinicalTrials.gov |
What this research studies
This research investigates how gammaherpesviruses, which infect over 95% of adults globally, influence the immune system and contribute to B cell lymphomas. The study focuses on a specific viral protein kinase that plays a crucial role in the virus's ability to persist in the host and evade immune responses. By examining the interactions between this viral protein and immune cells, particularly macrophages and B cells, the research aims to uncover mechanisms that could lead to new treatments or preventive strategies for virus-related lymphomas.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are at risk for or have been diagnosed with B cell lymphomas associated with gammaherpesvirus infections.
Not a fit: Patients who do not have gammaherpesvirus infections or related B cell lymphomas may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel therapeutic targets for preventing gammaherpesvirus-driven lymphomas.
How similar studies have performed: Previous research has shown that targeting viral mechanisms can lead to breakthroughs in understanding chronic infections and their associated cancers, suggesting potential success for this approach.
Where this research is happening
MILWAUKEE, UNITED STATES
- MEDICAL COLLEGE OF WISCONSIN — MILWAUKEE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TARAKANOVA, VERA L. — MEDICAL COLLEGE OF WISCONSIN
- Study coordinator: TARAKANOVA, VERA L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.