Understanding how a virus linked to cancer replicates in the body
Epigenetic Regulation of KSHV Genome Replication
['FUNDING_R01'] · UNIVERSITY OF PENNSYLVANIA · NIH-10669729
This study is looking at how a virus called KSHV behaves in people with weakened immune systems, like those with AIDS, to help us understand how it can lead to certain cancers, with the hope of finding better treatments for those affected.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10669729 on ClinicalTrials.gov |
What this research studies
This research investigates the Kaposi's sarcoma-associated herpesvirus (KSHV), which is known to cause certain cancers in individuals with weakened immune systems, particularly those with AIDS. The study focuses on how KSHV replicates in both latent and active states, examining the role of specific proteins that facilitate this process. By utilizing advanced techniques to analyze the virus's genetic material, the research aims to uncover new insights into the mechanisms of KSHV replication and its implications for cancer development. Patients may benefit from a better understanding of KSHV's behavior, which could lead to improved treatment strategies for related cancers.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Kaposi's sarcoma, body cavity-based lymphomas, or those with AIDS who are at risk for these conditions.
Not a fit: Patients who do not have KSHV-related cancers or are not immunocompromised may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for cancers associated with KSHV, potentially improving outcomes for affected patients.
How similar studies have performed: Previous research has shown promising results in understanding viral replication mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ROBERTSON, ERLE S. — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: ROBERTSON, ERLE S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome, Acquired Immuno-Deficiency Syndrome, Acquired Immunologic Deficiency Syndrome, Acquired Immunodeficiency Syndrome