Understanding how a virus controls its dormant state
Transcriptional Control of Human Cytomegalovirus Latency
['FUNDING_R01'] · UNIVERSITY OF WISCONSIN-MADISON · NIH-11097253
This study is looking at how the human cytomegalovirus (HCMV) stays hidden in the body without causing problems, focusing on a special protein called the Pentamer that helps the virus switch between being active and inactive, which could help us find better ways to treat people with HCMV.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WISCONSIN-MADISON (nih funded) |
| Locations | 1 site (MADISON, UNITED STATES) |
| Trial ID | NIH-11097253 on ClinicalTrials.gov |
What this research studies
This research investigates how the human cytomegalovirus (HCMV) maintains latency, a dormant state where the virus is present but not actively causing disease. The researchers focus on a protein complex called the Pentamer, which plays a crucial role in regulating the virus's ability to switch between active and latent phases. By creating genetically matched virus strains, they aim to explore how different versions of the Pentamer influence the virus's behavior in various cell types, including those from patients. This work could lead to new insights into how HCMV persists in the body and how it might be targeted in treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with compromised immune systems, such as those living with HIV/AIDS or undergoing organ transplantation.
Not a fit: Patients who are healthy and do not have any underlying immune deficiencies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for managing HCMV infections, particularly in immunocompromised patients.
How similar studies have performed: Previous research has shown success in understanding viral latency mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
MADISON, UNITED STATES
- UNIVERSITY OF WISCONSIN-MADISON — MADISON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KALEJTA, ROBERT F — UNIVERSITY OF WISCONSIN-MADISON
- Study coordinator: KALEJTA, ROBERT F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome, Acquired Immunodeficiency Syndrome, Cancers