Understanding how a virus causes severe disease and how it assembles
Reverse-engineering a viral Swiss army knife: Crimean-Congo hemorrhagic fever virus glycoprotein functions in assembly, entry, and in vivo pathogenesis
This study is looking into how the Crimean-Congo hemorrhagic fever virus works and interacts with our immune system, which could help scientists create better treatments and vaccines for this serious illness.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-10945276 on NIH RePORTER |
What this research studies
This research investigates the Crimean-Congo hemorrhagic fever virus (CCHFV), which leads to severe and often fatal hemorrhagic disease. The project aims to uncover the complex processes involved in the virus's assembly and entry into host cells, as well as its interactions with the immune system. By utilizing advanced techniques in virology and structural biology, the research team will explore how the virus's glycoproteins function and contribute to disease. This knowledge could pave the way for developing effective treatments and vaccines against this dangerous virus.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals living in endemic regions of CCHFV, particularly in Europe, Asia, and Africa.
Not a fit: Patients who do not reside in areas where CCHFV is endemic may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective vaccines or treatments for Crimean-Congo hemorrhagic fever, potentially saving lives.
How similar studies have performed: While research on CCHFV is ongoing, this specific approach to understanding its glycoprotein functions is novel and has not been extensively tested in previous studies.
Where this research is happening
Bronx, United States
- Albert Einstein College of Medicine — Bronx, United States (Active)
Researchers
- Principal investigator: Chandran, Kartik — Albert Einstein College of Medicine
- Study coordinator: Chandran, Kartik
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.