Understanding how a virus causes severe disease and how it assembles
Official title: Reverse-engineering a viral Swiss army knife: Crimean-Congo hemorrhagic fever virus glycoprotein functions in assembly, entry, and in vivo pathogenesis
Funded at Albert Einstein College of Medicine · NIH-10945276 · Data updated 2026-11-12
This study is looking into how the Crimean-Congo hemorrhagic fever virus works and interacts with our immune system, which could help scientists create better treatments and vaccines for this serious illness.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | August 15, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $558,501 |
| NIH project number | 1R01AI185073-01 |
| Project ID | NIH-10945276 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals living in endemic regions of CCHFV, particularly in Europe, Asia, and Africa.
✕Less likely to help
Patients who do not reside in areas where CCHFV is endemic may not receive direct benefits from this research.
What this research studies
This research investigates the Crimean-Congo hemorrhagic fever virus (CCHFV), which leads to severe and often fatal hemorrhagic disease. The project aims to uncover the complex processes involved in the virus's assembly and entry into host cells, as well as its interactions with the immune system. By utilizing advanced techniques in virology and structural biology, the research team will explore how the virus's glycoproteins function and contribute to disease. This knowledge could pave the way for developing effective treatments and vaccines against this dangerous virus.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective vaccines or treatments for Crimean-Congo hemorrhagic fever, potentially saving lives.
How similar studies have gone: While research on CCHFV is ongoing, this specific approach to understanding its glycoprotein functions is novel and has not been extensively tested in previous studies.
Where this research is happening
-
Albert Einstein College of Medicine
Bronx, United States Active
Researchers
- Principal investigator: Chandran, Kartik — Albert Einstein College of Medicine
- Study coordinator: Chandran, Kartik
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.