Understanding how a virus causes cancer and affects cell behavior
Molecular mechanisms governing the ubiquitination signaling during KSHV cell entry and tumorigenesis
This study is looking at how a virus called Kaposi sarcoma herpesvirus (KSHV) affects people with HIV/AIDS and may increase their risk of certain cancers, with the hope of finding new ways to treat these cancers.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-10643827 on NIH RePORTER |
What this research studies
This research investigates the role of Kaposi sarcoma herpesvirus (KSHV) in increasing the risk of certain cancers in individuals with HIV/AIDS. It focuses on how KSHV infection leads to chronic inflammation and the activation of specific proteins that promote cancer cell survival and proliferation. By examining the molecular mechanisms of protein ubiquitination, the study aims to uncover how KSHV enters cells and contributes to tumor development. Patients may benefit from insights that could lead to new treatment strategies for KSHV-related malignancies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV/AIDS who are at risk for KSHV-related cancers.
Not a fit: Patients who do not have HIV/AIDS or KSHV-related malignancies may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for treating cancers associated with KSHV in HIV-positive patients.
How similar studies have performed: Other research has shown promising results in understanding the role of viral infections in cancer development, indicating that this approach has potential for success.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Shembade, Noula Dattu — University of Miami School of Medicine
- Study coordinator: Shembade, Noula Dattu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.