Understanding how a virus causes a common cancer in people with HIV.
(PQ 6) New Models of KSHV Oncogenesis and KS Immune Environment
This study is looking at Kaposi's sarcoma, a type of cancer that affects people with HIV, especially in Sub-Saharan Africa, and aims to create new models to better understand how the cancer and the immune system interact, which could help find better treatments for those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11115987 on NIH RePORTER |
What this research studies
This research focuses on Kaposi's sarcoma (KS), a prevalent cancer among individuals living with HIV, particularly in Sub-Saharan Africa, caused by the Kaposi sarcoma herpesvirus (KSHV). The project aims to develop new models to better understand the disease and its immune environment, utilizing advanced techniques to study the interactions between KSHV and the immune system. By creating preclinical models, the research seeks to explore the complexities of KS lesions, which contain a mix of infected cells and immune responses. This comprehensive approach may lead to improved therapeutic strategies for KSHV-associated malignancies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Kaposi's sarcoma or other KSHV-associated conditions, particularly those living with HIV.
Not a fit: Patients who do not have KSHV-related diseases or are not living with HIV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better treatment options and improved outcomes for patients with Kaposi's sarcoma and other KSHV-related diseases.
How similar studies have performed: Previous research has shown promise in understanding KSHV-related diseases, but this approach aims to develop novel models that have not been extensively tested.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Cesarman, Ethel — Weill Medical Coll of Cornell Univ
- Study coordinator: Cesarman, Ethel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.