Understanding how a virus can cause persistent infections and its effects on the body
Cellular Programming in Persistent Versus Lytic Viral Infections
['FUNDING_OTHER'] · UNIVERSITY OF MAINE ORONO · NIH-11080316
This study is looking at how the JC virus behaves in the body, especially why it can stay harmless in healthy people but cause serious problems in those with weakened immune systems, like people with HIV, to help find new ways to prevent dangerous diseases like PML.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MAINE ORONO (nih funded) |
| Locations | 1 site (ORONO, UNITED STATES) |
| Trial ID | NIH-11080316 on ClinicalTrials.gov |
What this research studies
This research investigates the cellular factors involved in JC polyomavirus (JCPyV) infections, focusing on how these interactions can lead to either persistent or lytic infections. The study aims to understand the mechanisms behind JCPyV's ability to remain asymptomatic in healthy individuals while causing severe disease in immunocompromised patients, particularly those with HIV or undergoing immunomodulatory therapies. By exploring these virus-host cell interactions, the research seeks to identify potential therapeutic targets for preventing the progression to fatal diseases like progressive multifocal leukoencephalopathy (PML).
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with compromised immune systems, such as those living with HIV or receiving immunomodulatory therapies.
Not a fit: Patients with healthy immune systems and no risk factors for JCPyV-related diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for preventing or managing severe viral infections in immunocompromised patients.
How similar studies have performed: While the specific approach of this research is novel, previous studies have shown success in understanding viral pathogenesis and developing antiviral therapies.
Where this research is happening
ORONO, UNITED STATES
- UNIVERSITY OF MAINE ORONO — ORONO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MAGINNIS, MELISSA — UNIVERSITY OF MAINE ORONO
- Study coordinator: MAGINNIS, MELISSA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome, Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome, Acquired Immunodeficiency Syndrome Virus