Understanding how a virus affects salivary gland cells
Official title: Investigation of the role of HDAC activity in regulation of HCMV replication in the salivary epithelium
Funded at University of Cincinnati · NIH-10841638 · Data updated 2026-11-12
This study is looking at how a virus called cytomegalovirus (HCMV) affects salivary gland cells, especially to help protect pregnant women and people with weakened immune systems, and it’s testing new ways to stop the virus from spreading to find better treatments.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | May 16, 2023 |
| Project end | April 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $202,500 |
| NIH project number | 5R21AI173933-02 |
| Project ID | NIH-10841638 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit include adults who are immunocompromised or at risk of HCMV-related complications.
✕Less likely to help
Patients who are not affected by HCMV or do not have any related health conditions may not receive benefit from this research.
What this research studies
This research investigates the human cytomegalovirus (HCMV), which poses significant health risks, particularly to fetuses and immunocompromised individuals. The study utilizes a novel in vitro model called 'salispheres' to explore how HCMV replicates in salivary gland cells. By examining the role of histone deacetylase (HDAC) inhibitors, the research aims to uncover mechanisms that could lead to better antiviral therapies. Patients may benefit from insights gained regarding HCMV's behavior and potential treatment options.
Why it matters
Potential benefit: If successful, this research could lead to improved antiviral therapies for HCMV infections.
How similar studies have gone: Previous research has shown promise in using HDAC inhibitors for viral infections, indicating potential for success in this approach.
Where this research is happening
-
University of Cincinnati
Cincinnati, United States Active
Researchers
- Principal investigator: Miller, William E — University of Cincinnati
- Study coordinator: Miller, William E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.