Understanding how a virus affects HIV persistence in the body
Role of RhCMV in shaping the SIV proviral landscape
This study is looking at how Cytomegalovirus (CMV) might help HIV-1 stay in the body by making certain immune cells grow, and it aims to find ways to reduce the hidden HIV in people living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tulane University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project ID | NIH-11021049 on NIH RePORTER |
What this research studies
This research investigates the role of Cytomegalovirus (CMV) in the persistence of HIV-1 infection by examining how CMV may stimulate the proliferation of infected memory CD4 T cells. These cells harbor HIV-1 proviruses, which can remain dormant and contribute to the difficulty of curing HIV. The study aims to identify specific antigens related to CMV that may influence the expansion of these infected cells, potentially leading to new strategies for reducing the HIV reservoir in patients. By employing a multidisciplinary approach, the research seeks to clarify the mechanisms behind HIV persistence during antiretroviral therapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are also coinfected with Cytomegalovirus.
Not a fit: Patients who are not living with HIV or those without CMV coinfection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for reducing the HIV reservoir, potentially paving the way for a cure.
How similar studies have performed: While the specific approach of linking CMV to HIV persistence is novel, related studies have shown that understanding viral interactions can lead to advancements in HIV treatment.
Where this research is happening
New Orleans, United States
- Tulane University of Louisiana — New Orleans, United States (Active)
Researchers
- Principal investigator: Mudd, Joseph Christopher — Tulane University of Louisiana
- Study coordinator: Mudd, Joseph Christopher
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.