Understanding how a virus affects cancer cell survival and growth
Transcriptional Control of Cellular Survival and Proliferation in KSHV-transformed B Cells
This study is looking at how a protein called IRF4 helps cancer cells grow in a type of blood cancer linked to a virus, and it hopes to find new treatment options that could help patients with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10795960 on NIH RePORTER |
What this research studies
This research investigates the role of a specific protein, IRF4, in the survival and proliferation of cancer cells transformed by the Kaposi’s sarcoma-associated herpesvirus (KSHV), particularly in a type of blood cancer known as primary effusion lymphoma (PEL). The researchers aim to uncover how KSHV influences IRF4 and its relationship with another cancer-related gene, MYC. By analyzing the molecular mechanisms involved, the study seeks to identify potential new treatment strategies for patients affected by this cancer. Patients may benefit from insights that could lead to innovative therapies targeting these cancer pathways.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with primary effusion lymphoma or other KSHV-related cancers.
Not a fit: Patients with cancers not related to KSHV or those without a diagnosis of primary effusion lymphoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating blood cancers associated with KSHV, improving outcomes for affected patients.
How similar studies have performed: Previous research has shown promising results in understanding the role of transcription factors in cancer, suggesting that this approach may yield valuable insights.
Where this research is happening
Chicago, United States
- Northwestern University at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Gottwein, Eva Henriette — Northwestern University at Chicago
- Study coordinator: Gottwein, Eva Henriette
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.