Understanding how a virus affects blood vessel function
Role of Type I IFN Signaling in Seoul Orthohantavirus Pathogenesis
['FUNDING_R01'] · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · NIH-10868600
This study is looking at how a virus that causes a serious illness called hemorrhagic fever affects the body, especially how it impacts blood vessel cells, and it hopes to find new ways to help treat patients who are dealing with this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR (nih funded) |
| Locations | 1 site (ALBUQUERQUE, UNITED STATES) |
| Trial ID | NIH-10868600 on ClinicalTrials.gov |
What this research studies
This research investigates the role of type I interferon signaling in the pathogenesis of Seoul orthohantavirus, which causes hemorrhagic fever with renal syndrome (HFRS). The study focuses on how this virus targets endothelial cells, leading to vascular leakage and dysfunction. By examining the immune response in both human and animal models, the research aims to uncover the mechanisms behind the virus's effects and identify potential therapeutic targets. Patients may benefit from insights gained into the disease process and the development of new treatments.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit include individuals at risk of hantavirus infections, particularly those in endemic regions.
Not a fit: Patients with other viral infections unrelated to hantaviruses may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating hemorrhagic fever with renal syndrome.
How similar studies have performed: Previous research has shown that type I interferon can limit hantavirus replication, indicating potential for success in this area.
Where this research is happening
ALBUQUERQUE, UNITED STATES
- UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR — ALBUQUERQUE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KELL, ALISON — UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
- Study coordinator: KELL, ALISON
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.