Understanding how a viral protein interacts with cell membranes and trafficking pathways
Official title: Membrane Spanning and Subcellular Trafficking Mechanisms of a Viral Capsid Protein- Lessons from a Master Cell Biologist
Funded at University of Arizona · NIH-11017716 · Data updated 2026-11-12
This study is looking at how a part of the HPV virus interacts with our cells when it first tries to infect us, which could help us understand how viruses work and lead to new ways to treat infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project start | February 1, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $341,547 |
| NIH project number | 5R35GM152143-02 |
| Project ID | NIH-11017716 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for HPV infection or those with HPV-related conditions.
✕Less likely to help
Patients who are not infected with HPV or do not have HPV-related health issues may not benefit from this research.
What this research studies
This research investigates the mechanisms by which the human papillomavirus (HPV) L2 capsid protein interacts with cellular membranes during the early stages of infection. By studying how this viral protein manipulates cellular signaling and transport pathways, the research aims to uncover new insights into cellular biology. The approach includes examining the role of various cellular components and conditions that affect the trafficking of the L2 protein within cells. This work could lead to a better understanding of how viruses exploit cellular mechanisms, which may inform future therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating HPV infections by targeting the mechanisms of viral entry and trafficking.
How similar studies have gone: Previous research has shown success in understanding viral mechanisms through similar approaches, indicating potential for impactful findings in this area.
Where this research is happening
-
University of Arizona
Tucson, United States Active
Researchers
- Principal investigator: Campos, Samuel K — University of Arizona
- Study coordinator: Campos, Samuel K
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.