Understanding how a unique virus packages and replicates its genetic material
Official title: Mechanisms of genome packaging and replication by a filamentous dsRNA virus
Funded at Rice University · NIH-10738299 · Data updated 2026-11-12
This study is looking at how a specific virus, called Colletotrichum camelliae filamentous virus 1, works and copies itself, focusing on its unique shape and clever ways of sneaking into host cells without being fully exposed, which helps it avoid the body's defenses.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rice University NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | November 9, 2022 |
| Project end | October 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $188,447 |
| NIH project number | 5R21AI173858-02 |
| Project ID | NIH-10738299 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would be individuals involved in agricultural practices, particularly those dealing with plant viruses.
✕Less likely to help
Patients not involved in agriculture or those not affected by viral infections in plants may not receive any benefit from this research.
What this research studies
This research investigates the mechanisms by which the Colletotrichum camelliae filamentous virus 1 (CcFV-1) organizes and replicates its genome. The study focuses on the virus's filamentous structure and how it manages to transcribe its genetic material without fully uncoating during host entry, which helps it evade the host's defense mechanisms. By examining the viral proteins and their interactions, the research aims to uncover the unique properties of this virus that differentiate it from typical dsRNA viruses. The methodology includes advanced techniques such as cryo-electron microscopy to visualize the virus's structure and function.
Why it matters
Potential benefit: If successful, this research could lead to new insights into viral replication mechanisms, potentially informing strategies for controlling viral infections in agriculture.
How similar studies have gone: While the specific mechanisms of CcFV-1 are novel, similar research on other dsRNA viruses has shown promising results in understanding viral behavior and replication.
Where this research is happening
-
Rice University
Houston, United States Active
Researchers
- Principal investigator: Tao, Yizhi Jane — Rice University
- Study coordinator: Tao, Yizhi Jane
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.