Understanding how a unique nematode survives extreme stress
Official title: Investigating the molecular basis of evolved stress resilience in a subterrestrial nematode
Funded at American University · NIH-10438979 · Data updated 2026-11-12
This study is looking at how a unique worm from deep underground in South Africa survives tough conditions like extreme heat and low oxygen, and it aims to understand the genes that help it cope with stress, which could also give us clues about similar challenges in human health.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | American University NIH-funded |
| Lab location | 1 site (Washington, UNITED STATES) |
| Project start | June 7, 2022 |
| Project end | May 31, 2026 |
| Funding year | 2022 |
| Award (this year) | $425,184 |
| NIH project number | 1R15GM146207-01 |
| Project ID | NIH-10438979 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include individuals with conditions linked to cellular stress responses, such as autoimmune diseases, cancer, or neurodegenerative disorders.
✕Less likely to help
Patients with conditions unrelated to cellular stress responses or those not affected by the mechanisms being studied may not receive any benefit from this research.
What this research studies
This research investigates the molecular mechanisms that allow a special nematode, found deep underground in South Africa, to thrive in harsh conditions such as high temperatures and low oxygen. By studying the Unfolded Protein Response (UPR), a critical cellular stress response pathway, the researchers aim to uncover how this nematode adapts to stressors that would typically be lethal. The team will utilize RNA interference techniques to manipulate gene expression in the nematode, providing insights into the genes involved in stress resilience and their potential implications for human diseases.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating human diseases related to stress responses, such as cancer and neurodegenerative disorders.
How similar studies have gone: While the specific approach of studying this unique nematode is novel, research on stress response pathways has shown promise in understanding and treating various human diseases.
Where this research is happening
-
American University
Washington, United States Active
Researchers
- Principal investigator: Bracht, John Russell — American University
- Study coordinator: Bracht, John Russell
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.