Understanding how a toxic protein affects neurons in Alzheimer's disease
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['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA SANTA CRUZ · NIH-11086403
This study is looking at how a protein related to Alzheimer's disease affects brain cells, and it's for anyone interested in understanding how this protein can harm neurons and what that means for the disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA SANTA CRUZ (nih funded) |
| Locations | 1 site (SANTA CRUZ, UNITED STATES) |
| Trial ID | NIH-11086403 on ClinicalTrials.gov |
What this research studies
This research investigates the role of amyloid beta (Aβ), a protein linked to Alzheimer's disease, in damaging neurons. The team aims to understand how different forms of Aβ are taken up by brain cells and how this process contributes to toxicity. By using advanced techniques to create stable samples of Aβ, the researchers will analyze its structure and how it interacts with neurons. This collaborative effort involves experts from various fields to ensure a comprehensive approach to the problem.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk of developing it.
Not a fit: Patients with other forms of dementia unrelated to amyloid beta pathology may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating Alzheimer's disease by targeting the mechanisms of Aβ toxicity.
How similar studies have performed: Previous research has shown promise in understanding Aβ toxicity, but this approach aims to provide new insights that have not been fully explored.
Where this research is happening
SANTA CRUZ, UNITED STATES
- UNIVERSITY OF CALIFORNIA SANTA CRUZ — SANTA CRUZ, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RASKATOV, JEVGENIJ — UNIVERSITY OF CALIFORNIA SANTA CRUZ
- Study coordinator: RASKATOV, JEVGENIJ
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.