Understanding how a sugar-related protein helps our bodies fight off infections
Essential functions of OGT in host defense mechanism
This research explores how a protein called OGT, involved in sugar metabolism, helps our immune cells protect us from viruses and bacteria.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-11182579 on NIH RePORTER |
What this research studies
Our bodies' immune cells need energy from metabolism to fight off infections and diseases like cancer. This project focuses on a specific protein, OGT, which plays a key role in how cells use sugar and communicate. We want to understand how OGT helps immune cells respond to threats and how it might be involved in conditions like cancer and nerve disorders. By learning more about OGT, we hope to find new ways to boost our natural defenses.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation but could eventually benefit individuals with compromised immune systems, chronic infections, certain cancers, or neurodegenerative conditions.
Not a fit: Patients not experiencing issues with immune function, infections, or related diseases would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new strategies for strengthening the body's immune response against infections and potentially influence treatments for cancers and degenerative neurological disorders.
How similar studies have performed: While the broad concept of metabolic regulation in immune function is recognized, the specific role of OGT in host defense against pathogens is an emerging and less explored area of research.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Wen, Haitao — Ohio State University
- Study coordinator: Wen, Haitao
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.