Understanding how a specific type of cell death called pyroptosis works
Elucidating structural and functional mechanisms of pyroptosis
This study is looking at a special type of cell death that causes inflammation, focusing on a protein called gasdermin D, to find new ways to help people with diseases like Alzheimer's and cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11052663 on NIH RePORTER |
What this research studies
This research investigates pyroptosis, a form of cell death that causes inflammation and the release of cellular contents. It focuses on the role of gasdermin proteins, particularly gasdermin D, in mediating this process. By studying how these proteins interact and lead to cell rupture, the research aims to uncover mechanisms that could be targeted for therapeutic interventions. Patients may benefit from insights gained about diseases linked to inflammation and cell death, such as Alzheimer's and various cancers.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit include individuals with inflammatory diseases, neurodegenerative conditions like Alzheimer's, or certain cancers.
Not a fit: Patients with conditions unrelated to inflammation or cell death mechanisms may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases characterized by excessive inflammation and cell death.
How similar studies have performed: Previous research has shown promising results in understanding pyroptosis and its implications in various diseases, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Wu, Hao — Boston Children's Hospital
- Study coordinator: Wu, Hao
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.