Understanding how a specific transporter in mitochondria affects metabolism and diabetes
Mitochondrial BCAA transporter in physiology and disease
['FUNDING_R01'] · BETH ISRAEL DEACONESS MEDICAL CENTER · NIH-10746801
This study is looking at a new protein that helps your body process certain nutrients called branched-chain amino acids, and how it affects blood sugar control and insulin sensitivity, which is especially important for people with type 2 diabetes.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BETH ISRAEL DEACONESS MEDICAL CENTER (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10746801 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a newly identified mitochondrial transporter, SLC25A44, in the metabolism of branched-chain amino acids (BCAAs) and its impact on glucose regulation and insulin sensitivity. By studying brown adipose tissue (BAT), the research aims to uncover how this transporter influences the body's ability to process BCAAs and maintain glucose homeostasis. The approach includes both animal models and human studies to explore the mechanisms behind BCAA metabolism and its connection to conditions like type 2 diabetes.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with insulin resistance or type 2 diabetes, particularly those with elevated levels of branched-chain amino acids.
Not a fit: Patients without metabolic disorders or those who do not have elevated BCAA levels may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving glucose tolerance and insulin sensitivity in patients with diabetes.
How similar studies have performed: Previous studies have shown promising results in understanding the role of brown adipose tissue in metabolism, suggesting that this research could build on established findings.
Where this research is happening
BOSTON, UNITED STATES
- BETH ISRAEL DEACONESS MEDICAL CENTER — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KAJIMURA, SHINGO — BETH ISRAEL DEACONESS MEDICAL CENTER
- Study coordinator: KAJIMURA, SHINGO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: adult onset diabetes, Adult-Onset Diabetes Mellitus