Understanding how a specific transporter affects bone and tooth mineralization
Characterization of sodium dependent phosphate transporter 2 signaling in hard tissue mineralization
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF WASHINGTON · NIH-10845705
This study is looking at how a specific protein called PiT-2 affects the growth and hardening of bones and teeth, using animal models to see what happens when this protein is missing, which could help us find new ways to treat problems with bone and tooth development.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-10845705 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the sodium-dependent phosphate transporter PiT-2 in the development and mineralization of bones and teeth. By using animal models, the study aims to uncover how PiT-2 influences the differentiation and function of cells responsible for forming hard tissues, such as osteoblasts and ameloblasts. The researchers will explore the consequences of PiT-2 gene knockout on bone density and tooth development, providing insights into potential treatments for mineralization disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with known bone mineralization disorders or those at risk of developing such conditions.
Not a fit: Patients with fully developed bone structures and no history of mineralization disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for patients suffering from bone mineralization disorders, improving bone health and dental outcomes.
How similar studies have performed: Previous research has shown promising results in understanding the role of phosphate transporters in bone health, indicating that this approach has potential for significant findings.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WALCZAK, PHILIP ADAM — UNIVERSITY OF WASHINGTON
- Study coordinator: WALCZAK, PHILIP ADAM
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.