Understanding how a specific RNA affects heart function after injury
Deciphering the role of a circadian lncRNA in cardiac remodeling
This study is looking at a special molecule called Circa to see how it helps the heart heal after a heart attack, with the hope of finding new ways to improve recovery and heart health for people who have experienced heart injuries.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11055423 on NIH RePORTER |
What this research studies
This research investigates the role of a long non-coding RNA (lncRNA) called Circa in the heart's response to injury, particularly after a heart attack. The team will explore how Circa influences the remodeling of heart tissue by regulating gene expression and splicing processes. Using advanced techniques, they will identify the structures and interactions of Circa within heart cells and assess its functional importance through experiments in specially designed mouse models. The goal is to uncover new therapeutic targets for improving heart health post-injury.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of heart attacks or those at risk of heart failure due to ischemic cardiomyopathy.
Not a fit: Patients with non-cardiac related health issues or those without any history of heart disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart function and reduce mortality in patients recovering from heart attacks.
How similar studies have performed: Previous research has shown promise in targeting lncRNAs for cardiac therapies, suggesting that this approach could yield significant insights and advancements.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Zhang, Lilei — Baylor College of Medicine
- Study coordinator: Zhang, Lilei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.