Understanding how a specific RNA affects brain development
Official title: Elucidating the Spatiotemporal Regulation of a Long Non-Coding RNA Required for Neurodevelopment
Funded at Johns Hopkins University · NIH-11014023 · Data updated 2026-11-12
This study is looking at a special type of RNA that helps the brain grow and develop, to see how changes in it might be linked to brain disorders, with the hope that it can lead to better treatments for people with these conditions.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | December 1, 2022 |
| Project end | November 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $238,680 |
| NIH project number | 5K08NS119567-05 |
| Project ID | NIH-11014023 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with neurodevelopmental disorders or those at risk due to genetic factors.
✕Less likely to help
Patients with neurodevelopmental disorders not linked to non-coding RNA mutations may not benefit from this research.
What this research studies
This research investigates the role of a long non-coding RNA in brain development, focusing on how its regulation changes over time and in different locations within the brain. The project aims to identify mutations in non-coding regions of the genome that may contribute to neurodevelopmental disorders. By utilizing advanced techniques in genomics and bioinformatics, the research will provide insights into the genetic factors influencing brain function and development. Patients may benefit from improved understanding and potential new treatments for neurodevelopmental conditions.
Why it matters
Potential benefit: If successful, this research could lead to new insights and therapies for neurodevelopmental disorders.
How similar studies have gone: Previous research has shown promising results in understanding the role of non-coding RNAs in various genetic conditions, suggesting potential for success in this area.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Wontakal, Sandeep Nagaraj — Johns Hopkins University
- Study coordinator: Wontakal, Sandeep Nagaraj
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.