Understanding how a specific RNA affects brain cell activity
Official title: miR-137 Regulation of Intrinsic Excitability
Funded at Colorado State University · NIH-10719579 · Data updated 2026-11-12
This study is looking at how a tiny molecule called miR-137 affects the way brain cells communicate and work together, using fruit flies to see how changes in miR-137 might help us understand brain disorders like bipolar disorder and schizophrenia.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Colorado State University NIH-funded |
| Lab location | 1 site (Fort Collins, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $409,048 |
| NIH project number | 1R21NS133322-01 |
| Project ID | NIH-10719579 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with bipolar disorder or related brain disorders.
✕Less likely to help
Patients with brain disorders not associated with miR-137 or those without a diagnosis may not benefit from this research.
What this research studies
This research investigates the role of a small RNA molecule, miR-137, in regulating the electrical activity of brain cells. By using a model organism, Drosophila, the researchers will manipulate the expression of miR-137 and observe how it influences neuronal excitability and signaling. The study aims to identify the gene targets of miR-137 that are involved in these processes, which could provide insights into various brain disorders, including bipolar disorder and schizophrenia.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating brain disorders linked to miR-137.
How similar studies have gone: Previous research has shown that manipulating miRNAs can have significant effects on neuronal function, suggesting potential for success in this area.
Where this research is happening
-
Colorado State University
Fort Collins, United States Active
Researchers
- Principal investigator: Tsunoda, Susan L — Colorado State University
- Study coordinator: Tsunoda, Susan L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.