Understanding how a specific receptor influences liver cancer spread in colorectal cancer patients
Defining the mechanism of inositol 1,4,5-triphosphate receptor-mediated metastatic liver colonization in colorectal cancer
This study is looking at how a specific protein helps colorectal cancer spread to the liver, with the hope of finding new ways to improve treatment for patients facing this challenge.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10906929 on NIH RePORTER |
What this research studies
This research investigates the role of the inositol 1,4,5-triphosphate receptor (ITPR3) in the spread of colorectal cancer to the liver. By using advanced genetic screening techniques, the researchers aim to identify key genes and pathways that facilitate this metastatic process. The study focuses on how ITPR3 helps cancer cells overcome barriers in the liver environment, potentially leading to new therapeutic targets. Patients may benefit from insights that could improve treatment strategies for metastatic colorectal cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with metastatic colorectal cancer, particularly those with liver involvement.
Not a fit: Patients with early-stage colorectal cancer or those without liver metastasis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve survival rates for patients with metastatic colorectal cancer.
How similar studies have performed: Other research has shown promise in targeting similar pathways in cancer metastasis, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Moy, Ryan — Columbia University Health Sciences
- Study coordinator: Moy, Ryan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.