Understanding how a specific receptor influences cancer spread
Regulation of the metastasis promoting chemokine receptor ACKR3 by GPCR kinases, Gβγ and arrestins
This study is looking at how a specific receptor in cancer cells helps them spread in the body, and by understanding this, we hope to find new ways to stop cancer from spreading, which could help patients in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Purdue University NIH-funded |
| Lab location | 1 site (West Lafayette, United States) |
| Project ID | NIH-10854923 on NIH RePORTER |
What this research studies
This research investigates the role of the ACKR3 receptor in cancer metastasis, focusing on how it interacts with certain proteins called GPCR kinases and arrestins. By studying these interactions, the research aims to uncover the mechanisms that allow cancer cells to migrate and survive in the body. Patients may benefit from insights gained about how to potentially inhibit cancer spread, leading to new treatment strategies. The research involves laboratory experiments and analysis of cancer cell behavior.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cancers that exhibit high levels of ACKR3 and CXCR4 receptors.
Not a fit: Patients with cancers that do not express ACKR3 or CXCR4 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent cancer from spreading in patients.
How similar studies have performed: Previous research has shown promising results in targeting chemokine receptors for cancer treatment, indicating that this approach has potential for success.
Where this research is happening
West Lafayette, United States
- Purdue University — West Lafayette, United States (Active)
Researchers
- Principal investigator: Tesmer, John — Purdue University
- Study coordinator: Tesmer, John
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.