Understanding how a specific receptor in immune cells affects blood vessel function
Official title: Uncovering the function of EdnrB in perivascular macrophages
Funded at University of Pennsylvania · NIH-11116835 · Data updated 2026-11-12
This study is looking at how a specific receptor in immune cells near blood vessels helps keep our blood vessels healthy and supports our immune system, especially in conditions like tumors and fat tissue, which could lead to better treatments for patients.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | June 1, 2024 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $37,348 |
| NIH project number | 5F31HL170590-02 |
| Project ID | NIH-11116835 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions affecting blood vessels or immune responses, such as cancer or obesity.
✕Less likely to help
Patients with unrelated health issues or those not experiencing vascular or immune system problems may not benefit from this research.
What this research studies
This research investigates the role of the endothelin receptor-B (EdnrB) in perivascular macrophages, which are immune cells located near blood vessels. The study aims to uncover how these macrophages contribute to blood vessel health and immune responses, particularly in conditions like tumors and adipose tissue. By examining the molecular mechanisms that regulate EdnrB expression in these cells, the research seeks to fill critical gaps in our understanding of tissue-specific immune responses. Patients may benefit from insights gained about how to improve vascular health and immune function.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing blood vessel function and immune responses in various diseases.
How similar studies have gone: Previous research has shown promising results in understanding macrophage functions in other contexts, suggesting potential for success in this area as well.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Molina, William — University of Pennsylvania
- Study coordinator: Molina, William
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.