Understanding how a specific receptor helps bunyaviruses enter host cells
Official title: Characterizing the role of LDL related receptor 1 (Lrp1) as host entry factor for multiple bunyaviruses
Funded at Washington University · NIH-11017807 · Data updated 2026-11-12
This study is looking at how a specific protein in our cells helps certain viruses, like the ones that cause Rift Valley Fever and La Crosse virus, get inside, with the hope of finding new ways to treat these infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | March 14, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $767,375 |
| NIH project number | 5R01AI169850-03 |
| Project ID | NIH-11017807 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk of infection from bunyaviruses, particularly those living in areas where these viruses are prevalent.
✕Less likely to help
Patients who are not at risk of bunyavirus infections or those with existing conditions unrelated to these viruses may not benefit from this research.
What this research studies
This research investigates the role of LDL related receptor 1 (Lrp1) in facilitating the entry of various bunyaviruses into host cells. By studying how these viruses interact with Lrp1, researchers aim to uncover critical mechanisms that could lead to new therapeutic strategies. The project focuses on well-known bunyaviruses like Rift Valley Fever virus, Oropouche virus, and La Crosse virus, which pose significant health risks. The methodology includes laboratory experiments to analyze viral entry processes and receptor interactions.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective treatments for diseases caused by bunyaviruses, potentially reducing the impact of these infections on public health.
How similar studies have gone: Previous research has shown promise in understanding viral entry mechanisms, but this specific investigation into Lrp1 and bunyaviruses is relatively novel.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Amarasinghe, Gaya K. — Washington University
- Study coordinator: Amarasinghe, Gaya K.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.