Understanding how a specific receptor affects T cells during organ rejection
Role of the CD43 Receptor on Effector CD8+ T Cells During Acute Allograft Rejection
['FUNDING_OTHER'] · JOHNS HOPKINS UNIVERSITY · NIH-11125031
This study is looking at how a specific receptor on immune cells called CD8+ T cells affects kidney transplant patients, especially during times when the body might reject the new organ, to find better ways to prevent rejection and help transplants last longer.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11125031 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the CD43 receptor on CD8+ T cells, which are crucial in the body's immune response during acute organ rejection. By examining how these T cells respond to transplanted organs, the study aims to uncover mechanisms that lead to graft failure. The researchers will analyze the activation and behavior of CD43+ T cells in kidney transplant patients, focusing on their role in acute rejection episodes. This could lead to improved strategies for preventing organ rejection and enhancing long-term transplant success.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have received a kidney transplant and are at risk of acute rejection.
Not a fit: Patients who have not undergone organ transplantation or those with stable grafts without rejection episodes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better treatments that prevent acute rejection of transplanted organs, improving long-term survival rates for transplant patients.
How similar studies have performed: Previous research has shown promising results in understanding T cell responses in transplantation, but the specific role of CD43 in this context is still being explored.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KRUMMEY, SCOTT M — JOHNS HOPKINS UNIVERSITY
- Study coordinator: KRUMMEY, SCOTT M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.