Understanding how a specific receptor affects reproduction and metabolism
Official title: Role of the Melanocortin-3 Receptor in Regulation of the HPG Axis
Funded at University of Michigan at Ann Arbor · NIH-10984158 · Data updated 2026-11-12
This study is looking at how a specific receptor in the brain affects reproductive health by exploring its connection to metabolism, using specially modified mice to understand changes in things like puberty and reproductive cycles, which could help people with reproductive disorders related to metabolism.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $111,954 |
| NIH project number | 1K99HD113878-01A1 |
| Project ID | NIH-10984158 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing reproductive issues potentially linked to metabolic conditions.
✕Less likely to help
Patients with reproductive disorders not related to metabolic factors may not benefit from this research.
What this research studies
This research investigates the role of the melanocortin-3 receptor (MC3R) in regulating the hypothalamic-pituitary-gonadal (HPG) axis, which is crucial for reproductive health. By examining how this receptor interacts with metabolic signals, the study aims to uncover the neural pathways that influence reproductive function. The research utilizes animal models, particularly genetically modified mice, to observe changes in reproductive cycles and puberty onset related to MC3R activity. This approach may provide insights into reproductive disorders linked to metabolic issues.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for reproductive disorders that are influenced by metabolic health.
How similar studies have gone: Previous studies have shown that targeting similar receptors can lead to significant advancements in understanding reproductive health, suggesting a promising avenue for this research.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Porter, Danielle Tiffany — University of Michigan at Ann Arbor
- Study coordinator: Porter, Danielle Tiffany
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.