Understanding how a specific receptor affects nerve signaling under stress
Official title: Investigation of the G protein-coupled receptor FSHR-1 in multi-tissue neuromuscular signaling in normal and oxidative stress conditions
Funded at Butler University · NIH-10515156 · Data updated 2026-11-12
This study is looking at how a specific receptor in the nervous system helps nerves communicate and respond to stress, which could lead to new treatments for neurological disorders.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Butler University NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | August 20, 2022 |
| Project end | July 31, 2025 |
| Funding year | 2022 |
| Award (this year) | $422,267 |
| NIH project number | 1R15NS112918-01A1 |
| Project ID | NIH-10515156 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing neurological or neurodegenerative disorders, particularly those with symptoms related to oxidative stress.
✕Less likely to help
Patients with purely genetic neurological disorders unrelated to oxidative stress may not benefit from this research.
What this research studies
This research investigates the role of the FSHR-1 receptor in regulating nerve signaling and responses to oxidative stress. By studying the molecular mechanisms of synaptic transmission, the research aims to uncover how this receptor influences communication between tissues in the nervous system. The approach involves using model organisms to observe changes in neuromuscular signaling under both normal and stress conditions, providing insights into potential therapeutic targets for neurological disorders.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for neurological disorders linked to oxidative stress and synaptic transmission imbalances.
How similar studies have gone: Previous research has shown that targeting G protein-coupled receptors can lead to significant advancements in understanding and treating neurological conditions, suggesting a promising avenue for this investigation.
Where this research is happening
-
Butler University
Indianapolis, United States Active
Researchers
- Principal investigator: Kowalski, Jennifer — Butler University
- Study coordinator: Kowalski, Jennifer
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.