Understanding how a specific receptor affects liver disease related to alcohol consumption
Official title: Receptor Cd74 integrates meta-inflammation in alcohol-associated liver disease
Funded at University of Texas Hlth Sci Ctr Houston · NIH-10981593 · Data updated 2026-11-12
This study is looking at how a specific receptor in the liver, called CD74, works with a protein related to inflammation in people with alcohol-related liver disease, hoping to find new ways to help treat this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 1, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $442,898 |
| NIH project number | 1R01AA031250-01A1 |
| Project ID | NIH-10981593 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from alcohol-related liver disease, particularly those experiencing inflammation and liver damage.
✕Less likely to help
Patients with liver disease not associated with alcohol consumption may not benefit from this research.
What this research studies
This research investigates the role of a receptor called CD74 in the inflammation associated with alcohol-related liver disease. The study aims to explore how this receptor interacts with a protein known as macrophage migration inhibitory factor (MIF) in liver cells and immune cells. By examining these interactions, the researchers hope to uncover new insights into the mechanisms of liver damage caused by alcohol, which could lead to improved treatment strategies. The research will utilize animal models to analyze the effects of alcohol on liver inflammation and cell death.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for treating alcohol-related liver diseases.
How similar studies have gone: Previous research has shown promising results in understanding the role of inflammation in liver diseases, but the specific approach of targeting CD74 in alcohol-related liver disease is relatively novel.
Where this research is happening
-
University of Texas Hlth Sci Ctr Houston
Houston, United States Active
Researchers
- Principal investigator: Poulsen, Kyle — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Poulsen, Kyle
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.